ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives.

Like meropenem, but unlike imipenem, it has a 1-beta-methyl substituent and does not require protection with an inhibitor of human renal dihydropeptidase I. IM nisert is contraindicated in patients with an amide local anesthetic hypersensitivity.

If diarrhea develops during therapy, the pacjage should be discontinued. During clinical studies, seizures occurred in 0. The toxin produced by Clostridium difficile is a primary cause of pseudomembranous colitis. For the treatment of complicated intraabdominal infections.

Ertapenem Sodium Injection – Par Sterile Products – Products

Affected cytochrome P isoenzymes: Use within 1 hour after preparation. IV or Ertaepnem broad-spectrum carbapenem antibiotic stable against beta-lactamases Used to treat UTI, skin, pelvic, intraabdominal infections and community-acquired pneumonia; used for colorectal surgical prophylaxis Once-daily dosing may be advantageous, but no P.

In vitro and in vivo animal studies have demonstrated that the major pharmacodynamic parameter that determines efficacy for beta-lactams is the amount of time free non-protein bound drug concentrations exceed the minimum inhibitory concentration MIC of the organism free T above the MIC. Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce paxkage of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria.

The MICs are defined for Enterobacteriaceae as susceptible at 0. The concentration in breast milk 24 hours after a 1 g dose ranged from less than 0. Clinical trial data and other reported clinical experience has not identified differences in responses between the elderly and younger adult patients, but greater sensitivity of some older individuals cannot be ruled out. Shake well to dissolve. The diluted solution may be refrigerated for up to 24 hours 5 degrees C and used within 4 hours after removal from refrigeration.

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May consider IM administration as an alternative to IV administration in the treatment of infections where IM therapy is appropriate; however, only administer via IM injection for 7 days. Major Concomitant use of carbapenems doripenem, ertapenem, imipenem, meropenem and valproic acid is not recommended.

However, specific intrinsic or acquired beta-lactamases, generally called carbapenemases, can hydrolyze the carbapenems. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.

Patients who have experienced anaphylactic reactions to penicillins or cephalosporins should not receive ertapenem. Guidelines recommend ertapenem for 4 to 7 days for community-acquired infections. If focal tremor or myoclonic seizures occur, patients should be evaluated neurologically. Activity is maintained by the parent drug ertapfnem the beta-lactam ring is hydrolyzed resulting in an inactive metabolite. Almost all antibacterial agents have been associated with pseudomembranous colitis antibiotic-associated colitis which may range in severity from insret to life-threatening.

Consider transitioning to an appropriate oral therapy after at least 3 days of parenteral therapy, once clinical improvement has been demonstrated. Immediately transfer the appropriate amount of the reconstituted vial to diluent.

In milder cases, pacoage colitis may respond to discontinuation of the offending agent. Infuse IV over 30 minutes.

Ertapenem should be prescribed with caution to patients with inflammatory pwckage disease such as ulcerative colitis or other GI disease.

In the colon, overgrowth of Clostridia may exist when normal flora is altered subsequent to antibacterial administration.

The MICs are defined for Staphylococcus sp. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy ettapenem OCs and antibiotics was reported. Use within 6 hours if stored at room temperature packaeg degrees C. Case studies have reported ertapenem causing decreases in valproic acid and divalproex serum concentrations when ertapenem was added imsert their regimen; discontinuation of ertapenem resulted in increased valproic acid concentrations.

In animal studies evaluating doses 1. Safety and efficacy have not been established. Monitor patients for signs and symptoms of bleeding. There are no data on the effects of ertapenem on the breast-fed infant or on milk production.

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Invanz (ertapenem) dose, indications, adverse effects, interactions from

In inserr of a cat or dog bite, preemptive antimicrobial therapy is recommended for 3 to 5 days for patients who are immunocompromised, asplenic, have advanced liver disease, have edema of the bite area, have moderate to severe injuries, particularly of the hand or face, or have penetrating injuries to the periosteum or joint capsule.

If an allergic reaction occurs, discontinue the drug and initiate appropriate emergency treatment with epinephrine, oxygen, IV steroids, intubation or other therapy as indicated.

Your Name Your name is required. Theoretically, efflux activity plus loss of membrane permeability is less likely to happen in vivo than AmpC beta-lactamase expression and loss of membrane permeability. Following diagnosis of pseudomembranous colitis, therapeutic measures should onsert instituted. Related Drug Information Drug Summary.

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These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending packxge additional method of contraception during short-term antibiotic use may be justified.

Anticonvulsive therapy should be continued in patients with a known seizure disorder. Your email has been sent. There is a maximum proportion of PBPs that can be acylated; therefore, once maximum acylation has occurred, killing rates cannot increase. If possible, avoid coadministration. Patients at greater risk for seizures may include: Ertapenem distributes into human breast milk and crosses the rat placental barrier. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may imsert advisable in selected circumstances.

Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. However, it is theorized that a combination of resistance mechanisms is required for significant carbapenem resistance. Agitate well to form a solution.