and pharmacological properties of Kigelia africana (Lam.) Balmkheera, Isopinnatal, Kigelin, Chemical constituents, Medicinal properties. Objective: Kigelia africana, a tropical tree, which has long been used in African . Analytical grade solvents (Fischer chemicals) were used for isolation and. cancer with drugs (pharmacotherapy) or with chemical compounds ( chemotherapy) in family comprises 21 species, of which Kigelia africana. (Lam. ) Benth is.

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J Sci Food Agric.

Medicinal herbs in Malawi and their uses. The root bark is used for the treatment of cancer of the uterus Msouthi and Mangombo, Helvetica Chimica Acta, Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines.

The structures of phenolic compounds which exhibited antioxidant activity in the ethyl acetate fraction would need to be elucidated. The compounds were identified on the basis of their retention times and mass-spectral fragmentation patterns compared with those of reference compounds stored on the spectrometer database and the NIST library.

Comparison of NCCLS and 3- 4,5-dimethylthiazyl -2, 5-diphenyl-2H-tetrazolium bromide MTT methods of in vitro susceptibility testing of filamentous fungi and development of a new simplified method.

It is also reported for its antioxidant activities Wenceslau et al. In view of this, we have investigated the in vitro antioxidant effect of these extracts by DPPH chemivals and examined the phytochemicals in each extract. The residual plant material was further extracted with ethyl acetate to afford Antioxidant compounds are abundantly available in plants and play an important role in scavenging free radicals, thus providing protection to humans against oxidative DNA damage Ponnan et afridana.


The antioxidant acivity was measured using DPPH assay.

The antioxidant activity which correlated with the chrmicals phenolic content of the extracts was assumed to be from the total phenolic content of the extracts. Phenylpropanoid and phenylethanoid derivatives from Kigelia pinnata DC.

Lately, it has been reported that incorporation of trans fatty acids into the phospholipids of the membranes affected its properties and mainly the activity of enzymes attached to chemivals membrane, in fact, in recent times a positive relation has been established between allergic diseases and trans fatty acid consumption Kritchevsky, [ 26 ]; Stender and Dyerberg, [ 49 ].

Lapachol has been reportedly isolated from the root of the plant previously Govindachari et al.

Chemical composition and antioxidant potentials of Kigelia pinnata root oil and extracts

Author information Article notes Copyright and License information Disclaimer. Antioxidant activities of Iranian Corn Silk. KPRM showed the peak activity at 0. Medicinal plant and traditional medicine in Africa. The hexanes and the chloroform extracts of K. Singapore Journal of Scientific Research Volume 2 2: New Constituents of Kigelia pinnata Leaves.

N Engl J Med. The remaining plant material was subsequently extracted with ethyl acetate for five days. Adeosun1 and Gabriel A.

Chemical composition and antioxidant potentials of Kigelia pinnata root oil and extracts

Fractionation scheme for K. Inhibition of activator protein-1, nf-k b, and mapks and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. A similar interaction is observed between C-2 and C The relative percentages of the identified compounds are listed in Table 1. Samples and sample preparation: The plant is endemic in the south, central and West Africa Burkill, ; Olatunji and Atolani, Novel lapachol derivatives and their antioxidant activity.


Phytochemical screening of the plant extracts A small portion of the dry extract was used for the phytochemical screening for compounds chmeicals tannins, phlobatannins, flavonoids, terpenoids, alkaloids, cardiac glycosides, anthraquinone, saponins, and steroids in accordance with methods described by Harborne [ 21 ]Trease and Evans [ 50 ] and Sofowora [ 48 ] with minor modifications.

Antioxidant and free radical scavenging activity of Feijoa sallowiana fruits peel and leaves.

The extract was decanted, filtered and concentrated under reduced pressure using rotary evaporator to afford mg of a yellow oil which was coded KPRH. Deletion of the cyclin-dependent kinase-4 inhibitor gene inmultiple human cancers. Aqueous extract of the bark of Kigelia africana reverses early testicular damage induced by methanol extract of Carica papaya. The compound was later obtained as a white precipitate from the oil mixture.

Further, the results of the in vitro assays corroborate the traditional utility of kigeelia plant in medicine.

New Constituents of Kigelia pinnata Leaves – SciAlert Responsive Version

The present study provides basic data on the natural antioxidant potential of Kigelia pinnata root for the food, africanz or cosmetic industries, and also offers scientific reference for the large scale usage and exploitation of Kigelia pinnata as a vital resource.

The MS data obtained is consistent with literature Snyder et al. Anti-inflammatory activity of verminoside from Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. Post-hoc test analysis was done using the Duncan multiple comparison test.